Ngunnawal, Australia 35.28°S · 149.13°E

Systems architect

Bringing coherence to complex fields.

Across software, infrastructure, AI and computational science.

See the work Reach out

J. Bones — AUS

∞

Starting points

Papers across Nature & Science

Apps shaped for defence

Discipline

About

One discipline, many domains.

Whatever it is — molecular scaffolds, infrastructure, interfaces, data, people — experienced as one thing: coherence that thrives through change.

More about me

Research, Data & Science

Atomic-scale simulation exposing the mechanics of disease.

Systems & Infrastructure

Foundations that hold their shape under load.

Applications & Product

Software that changes how people think.

Now building In development

EndPoint

PhD · Drug-discovery platform

Structural biology arrives fragmented — every structure in its own state, re-prepared by hand. EndPoint creates a structure library, discovers the conformation end-points, and constructs pristine simulation-ready molecular-dynamics systems through one reproducible pipeline.

Configuration is the source of truth, so the same method transfers from lupus and TLR to any receptor. Promising leads surface sooner, on a footing every result can be trusted on.

See it on the projects page

Now building Public soon

BoneShell

Open source · Dev tooling

Dotfiles scatter and drift. BoneShell makes the repo authoritative — one command, and a fresh macOS or Linux machine is identically home. Beautiful. Powerful. Prepared.

One visual palette cascades to every tool; the machines you work across thread into a single chain that AI agents can move along. Configuration becomes CI tested infrastructure — coherence you carry between systems that can adapt with you.

Built to be beautiful, customised to your own flavour, and kept.

See it on the projects page

Projects

The same discipline, different domains.

All projects

Platform · CTO MVP

SelfTherapy

Mental-health support across web, iOS and Android.

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Platform · Defence MVP

MindCompass

The same support translated for military minds.

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System · Defence

FABHUMS

Bridge structural-health monitoring. Sensors, hardware, operators — one interface.

Explore

Research · Nature 2022

TLR7 gain-of-function genetic variation causes human lupus

Structural impact of a gain-of-function mutation in the TLR7 immune receptor as a cause of human lupus — atomic-scale simulation informing real-world disease.

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Research · Science Adv. 2023

DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency

Computational biophysics on the DECTIN-1 immune-system protein as a modifier in CTLA-4 haploinsufficiency.

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Research · Nature Immunology 2026

2′-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity

How 2′-O-methyl-guanosine RNA fragments antagonise the TLR7 and TLR8 receptors to limit autoimmunity.

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Alongside

If the work resonates, say hello.

It's a practice I keep in the open. Bring a hard problem, a question, or just a conversation.

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